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Sabtu, 30 April 2011

Video captures cellular 'workhorses' in action (video tentang sel)

Video captures cellular 'workhorses' in action
Scientists at Yale University and in Grenoble France have succeeded in creating a movie showing the breakup of actin filaments, the thread-like structures inside cells that are crucial to their movement, maintenance and division.
Actin filaments are the muscular workhorses of our cells — pushing on membranes to move cells to the proper location within tissues and applying pressure within the interior to keep all working parts of the cell where they need to be. These filaments do their jobs through a mysterious process of continual splitting and reassembly.
video


Thread-like actin filaments, strong as commercial plastic, are the muscular workhorses of our cells -- pushing on membranes to move cells to the proper location within tissues and applying pressure within the interior to keep all working parts of the cell where they need to be. These filaments do their jobs through a mysterious process of continual splitting and reassembly. In the movie, filaments are caught in the act of disassembly. Filament ends are marked by red and green arrows and the severing events are indicated by pink arrows and yellow flashes. The images answer long-standing questions about just where these breaks occur. Credit: Cristian Suarez
Actin filaments are assembled and disassembled in a complex series of molecular events, known to be influenced by the protein cofilin. However, it was not known exactly where these breaks occur along the filaments, made up of actins monomer, which are as strong as commercial plastic.

Enrique De La Cruz, associate professor of molecular biophysics and biochemistry at Yale, and his French colleagues used fluorescent stains of cofilin which enabled them to create movies of this molecular disassembly. They used technology called total internal reflection fluorescence microscopy peer into the inner workings of the cell.






wow.... sungguh luarbiasa, pergerakan sel telah bisa dilihat dan difilmkan. "
Para ilmuwan di Yale University dan di Grenoble Perancis telah berhasil menciptakan sebuah film yang menunjukkan pecahnya filamen aktin, struktur seperti benang dalam sel yang penting untuk, pemeliharaan, pergerakan dan membelah diri.... kapan orang indonesia bisa meneliti sesuatu yang bermanfaat seperti mereka?... kita tunggu para profesor indonesia....


More information: The work is published in the April 28 issue of Current Biology.

Provided by Yale University (news : web)

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